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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:6651
Term: malathion
Definition: A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.
Chemical ID: MESH:D008294
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDMalathion results in decreased expression of BAX mRNAPMID:23774768
Baxincreases expressionEXP 6480464CTDMalathion results in increased expression of BAX proteinPMID:35274200
Baxmultiple interactionsEXP 6480464CTDcrocin inhibits the reaction [Malathion results in increased expression of BAX protein]PMID:35274200
Baxincreases expressionISOBax (Mus musculus)6480464CTDMalathion results in increased expression of BAX proteinPMID:32120800
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDMalathion results in increased expression of BAX proteinPMID:30769050
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDPlant Extracts inhibits the reaction [Malathion results in increased expression of BAX protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of BAX protein]PMID:32120800
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Malathion results in increased expression of BAX protein]PMID:30769050
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