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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551988
Species: Mus musculus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Acc ID: CHEBI:6651
Term: malathion
Definition: A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.
Chemical ID: MESH:D008294
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageEXP 6480464CTDMalathion results in increased cleavage of PARP1 proteinPMID:29027213
Parp1multiple interactionsEXP 6480464CTDMetoclopramide inhibits the reaction [Malathion results in increased cleavage of PARP1 protein]PMID:29027213
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