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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:66470
Term: (+)-sesamin
Definition: A lignan that consists of tetrahydro-1H,3H-furo[3,4-c]furan substituted by 1,3-benzodioxole groups at positions 1 and 4 (the 1S,3aR,4S,6aR stereoisomer). Isolated from Cinnamomum camphora, it exhibits cytotoxic activity.
Chemical ID: MESH:C054125
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2multiple interactionsEXP 6480464CTD6-chloro-2, 3, 4, 9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [sesamin inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of SOD2 protein]], 6-chloro-2, 3, 4, 9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [sesamin results in increased expression of and results in increased activity of SOD2 protein], sesamin inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of SOD2 protein], sesamin results in increased expression of and results in increased activity of SOD2 protein

PMID:24211423
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.