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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:66470
Term: (+)-sesamin
Definition: A lignan that consists of tetrahydro-1H,3H-furo[3,4-c]furan substituted by 1,3-benzodioxole groups at positions 1 and 4 (the 1S,3aR,4S,6aR stereoisomer). Isolated from Cinnamomum camphora, it exhibits cytotoxic activity.
Chemical ID: MESH:C054125
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6multiple interactionsEXP 6480464CTDsesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 mRNA]

PMID:19794909
Il6multiple interactionsISORGD:108026480464CTDsesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 mRNA], sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]

PMID:22919443
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.