Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11429
Species: Mus musculus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:66395
Term: miquelianin
Definition: A quercetin O-glycoside that consists of quercetin attached to a beta-D-glucuronopyranosyl moiety at position 3 via a glycosidic linkage. Isolated from Salvia and Phaseolus vulgaris, it exhibits antioxidant and antidepressant activities.
Chemical ID: MESH:C443401
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsISORGD:13441926480464CTDquercetin 3-O-glucuronide inhibits the reaction [[lipopolysaccharide E coli O55-B5 co-treated with TNF protein] results in increased expression of VCAM1 protein] quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased secretion of TNF protein]

PMID:17880982 PMID:23504962
Tnfmultiple interactionsISORGD:38766480464CTDquercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of TNF protein]

PMID:26190035
Go Back to source page   Continue to Ontology report