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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730892
Species: Homo sapiens
RGD Object: Gene
Symbol: NFKB1
Name: nuclear factor kappa B subunit 1
Acc ID: CHEBI:66309
Term: rocaglamide
Definition: An organic heterotricyclic compound that is 2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan substituted by hydroxy groups at positions 1 and 8b, methoxy groups at positions 6 and 8, a 4-methoxyphenyl group at position 3a, a phenyl group at position 3 and a N,N-dimethylcarbamoyl group at position 1. Isolated from Aglaia odorata and Aglaia duperreana, it exhibits antineoplastic activity.
Chemical ID: MESH:C107772
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFKB1decreases expressionEXP 6480464CTDrocaglamide results in decreased expression of NFKB1 proteinPMID:31433962
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