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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303073
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xbp1
Name: X-box binding protein 1
Acc ID: CHEBI:66262
Term: trierixin
Definition: A 21-membered macrocycle isolated from the fermentation broth of Streptomyces sp.AC654. It exhibits antineoplastic activity.
Chemical ID: MESH:C525271
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xbp1multiple interactionsISORGD:13527876480464CTDtrierixin inhibits the reaction [Thapsigargin results in increased expression of XBP1 mRNA], trierixin inhibits the reaction [Thapsigargin results in increased splicing of XBP1 mRNA]

PMID:17917237
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.