GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcc2 | decreases activity | ISO | Abcc2 (Rattus norvegicus) | 6480464 | CTD | verlukast results in decreased activity of ABCC2 protein; verlukast results in decreased activity of ABCC2 protein modified form | PMID:15904671 | Abcc2 | decreases activity | ISO | ABCC2 (Homo sapiens) | 6480464 | CTD | verlukast results in decreased activity of ABCC2 protein | PMID:15451006 PMID:15729621 PMID:16316932 PMID:19070657 PMID:19505989 PMID:20457140 PMID:25844889 PMID:29052767 | Abcc2 | multiple interactions | ISO | Abcc2 (Rattus norvegicus) | 6480464 | CTD | [verlukast results in decreased activity of ABCC2 protein] which results in decreased secretion of Resveratrol metabolite; ABCC2 protein affects the reaction [verlukast results in decreased secretion of Chenodeoxycholic Acid] | PMID:20089784 PMID:21262925 | Abcc2 | multiple interactions | ISO | ABCC2 (Homo sapiens) | 6480464 | CTD | [verlukast results in decreased activity of ABCC2 protein] which results in decreased export of Topotecan; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylaconine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylhypaconine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylmesaconine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of hypaconitine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of mesaconitine; [verlukast results in decreased activity of ABCC2 protein] which results in increased uptake of Vinblastine; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased export of Paclitaxel]; verlukast inhibits the reaction [ABCC2 protein results in increased export of Saquinavir]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of Leukotriene C4]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of zearalenol]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of Zearalenone]; verlukast inhibits the reaction [Bucladesine results in increased activity of ABCC2 protein] | PMID:19647055 PMID:19952419 PMID:20457140 PMID:23200901 PMID:25844889 PMID:27676153 PMID:29052767 PMID:32003934 | |
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