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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10368
Species: Mus musculus
RGD Object: Gene
Symbol: Abcc2
Name: ATP-binding cassette, sub-family member 2
Acc ID: CHEBI:6619
Term: MK 571
Definition: A quinoline that has formula C26H27ClN2O3S2.
Chemical ID: MESH:C059141
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2decreases activityISOAbcc2 (Rattus norvegicus)6480464CTDverlukast results in decreased activity of ABCC2 protein; verlukast results in decreased activity of ABCC2 protein modified formPMID:15904671
Abcc2decreases activityISOABCC2 (Homo sapiens)6480464CTDverlukast results in decreased activity of ABCC2 proteinPMID:15451006 PMID:15729621 PMID:16316932 PMID:19070657 PMID:19505989 PMID:20457140 PMID:25844889 PMID:29052767
Abcc2multiple interactionsISOAbcc2 (Rattus norvegicus)6480464CTD[verlukast results in decreased activity of ABCC2 protein] which results in decreased secretion of Resveratrol metabolite; ABCC2 protein affects the reaction [verlukast results in decreased secretion of Chenodeoxycholic Acid]PMID:20089784 PMID:21262925
Abcc2multiple interactionsISOABCC2 (Homo sapiens)6480464CTD[verlukast results in decreased activity of ABCC2 protein] which results in decreased export of Topotecan; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylaconine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylhypaconine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylmesaconine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of hypaconitine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of mesaconitine; [verlukast results in decreased activity of ABCC2 protein] which results in increased uptake of Vinblastine; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased export of Paclitaxel]; verlukast inhibits the reaction [ABCC2 protein results in increased export of Saquinavir]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of Leukotriene C4]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of zearalenol]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of Zearalenone]; verlukast inhibits the reaction [Bucladesine results in increased activity of ABCC2 protein]PMID:19647055 PMID:19952419 PMID:20457140 PMID:23200901 PMID:25844889 PMID:27676153 PMID:29052767 PMID:32003934
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