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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731977
Species: Mus musculus
RGD Object: Gene
Symbol: Cflar
Name: CASP8 and FADD-like apoptosis regulator
Acc ID: CHEBI:66103
Term: jaceosidin
Definition: A trihydroxyflavone that is flavone with hydroxy groups at positions 5, 7 and 4' and methoxy groups at positions 3' and 6. Isolated from Salvia tomentosa and Artemisia asiatica, it exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties.
Chemical ID: MESH:C477508
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cflardecreases expressionISOCFLAR (Homo sapiens)6480464CTDjaceosidin results in decreased expression of CFLAR mRNA; jaceosidin results in decreased expression of CFLAR proteinPMID:27729209
Cflarmultiple interactionsISOCFLAR (Homo sapiens)6480464CTDCFLAR protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; RELA protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; SP1 protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]PMID:27729209
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