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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:66103
Term: jaceosidin
Definition: A trihydroxyflavone that is flavone with hydroxy groups at positions 5, 7 and 4' and methoxy groups at positions 3' and 6. Isolated from Salvia tomentosa and Artemisia asiatica, it exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties.
Chemical ID: MESH:C477508
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageISORGD:13451186480464CTDjaceosidin results in increased cleavage of PARP1 protein

PMID:27729209
Parp1multiple interactionsISORGD:13451186480464CTDbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein] CFLAR protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein] MCL1 protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]

PMID:27729209
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