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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1597145
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Glb1
Name: galactosidase, beta 1
Acc ID: CHEBI:65899
Term: flavokawain B
Definition: A member of the class of chalcones that consists of trans-chalcone substituted by hydroxy group at positions 2' and methoxy groups at positions 4' and 6'. Isolated from Piper methysticum and Piper rusbyi, it exhibits antileishmanial, anti-inflammatory and antineoplastic activities.
Chemical ID: MESH:C452039
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Glb1increases expressionISOGLB1 (Homo sapiens)6480464CTDflavokawain B results in increased expression of GLB1 proteinPMID:30025493
Glb1multiple interactionsISOGLB1 (Homo sapiens)6480464CTD[ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of GLB1 protein; [Chloroquine co-treated with flavokawain B] results in decreased expression of GLB1 proteinPMID:30025493
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