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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734432
Species: Mus musculus
RGD Object: Gene
Symbol: Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Acc ID: CHEBI:65737
Term: demethoxycurcumin
Definition: A beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen. It is found in Curcuma zedoaria and Etlingera elatior.
Chemical ID: MESH:C050229
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects localizationEXP 6480464CTDdemethoxycurcumin affects the localization of NFE2L2 proteinPMID:17535857
Nfe2l2multiple interactionsEXP 6480464CTD[demethoxycurcumin co-treated with bisdemethoxycurcumin] affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]PMID:17535857
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