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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732502
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:65737
Term: demethoxycurcumin
Definition: A beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen. It is found in Curcuma zedoaria and Etlingera elatior.
Chemical ID: MESH:C050229
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK1multiple interactionsEXP 6480464CTD[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]PMID:35752269
MAPK1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDdemethoxycurcumin results in increased phosphorylation of MAPK1 proteinPMID:17535857
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