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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731002
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP3
Name: caspase 3
Acc ID: CHEBI:65737
Term: demethoxycurcumin
Definition: A beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen. It is found in Curcuma zedoaria and Etlingera elatior.
Chemical ID: MESH:C050229
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP3decreases expressionEXP 6480464CTDdemethoxycurcumin results in decreased expression of CASP3 mRNAPMID:33582110
CASP3increases cleavageEXP 6480464CTDdemethoxycurcumin results in increased cleavage of CASP3 proteinPMID:34291863
CASP3multiple interactionsEXP 6480464CTDdemethoxycurcumin inhibits the reaction [Peroxynitrous Acid results in increased activity of CASP3 protein]PMID:19188863
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