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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344104
Species: Homo sapiens
RGD Object: Gene
Symbol: IRF3
Name: interferon regulatory factor 3
Acc ID: CHEBI:65686
Term: cudratricusxanthone A
Definition: A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 2, 3, 6 and 8, an isoprenyl group at position 1 and a 2-methylbut-3-en-2-yl group at position 5. It is isolated from the root barks of Cudrania tricuspidata and exhibits cytotoxicity towards human cancer cell lines.
Chemical ID: MESH:C533013
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IRF3multiple interactionsISOIrf3 (Mus musculus)6480464CTDcudratricusxanthone A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased expression of IRF3 protein]PMID:31350693
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