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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551988
Species: Mus musculus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Acc ID: CHEBI:65585
Term: carnosic acid
Definition: An abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from rosemary (Rosmarinus officinalis) and common sage (Salvia officinalis) and exhibits anti-angiogenic, antineoplastic, antioxidant and anti-HIV activity.
Chemical ID: MESH:C018381
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1decreases expressionISOPARP1 (Homo sapiens)6480464CTDsalvin results in decreased expression of PARP1 proteinPMID:28918123
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDsalvin results in increased cleavage of PARP1 proteinPMID:28918123
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [salvin results in increased cleavage of PARP1 protein]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]PMID:25446857 PMID:28918123 PMID:30707903 PMID:31705926
Parp1multiple interactionsISOParp1 (Rattus norvegicus)6480464CTDsalvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]PMID:25446857
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