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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3908
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tsc2
Name: TSC complex subunit 2
Acc ID: CHEBI:65415
Term: antroquinonol
Definition: An enone that is cyclohex-2-en-1-one substituted by a hydroxy group at position 4, methoxy groups at positions 2 and 3, a methyl group at position 6 and a (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl group at position 5 (the 4R,5R,6R stereoisomer). It is isolated from the solid-state fermented mycelium of the fungus Antrodia camphorata and has been found to exhibit potent cytotoxicity against a number of human cancer cell lines. However, a synthesis-enabled biological re-examination published in 2016, revealed minimal in vitro and in vivo antitumour activity in preclinical models.
Chemical ID: MESH:C545357
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tsc2multiple interactionsISOTSC2 (Homo sapiens)6480464CTDantroquinonol promotes the reaction [TSC2 protein binds to TSC1 protein]PMID:19723512
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