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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621628
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a12
Name: solute carrier family 22 member 12
Acc ID: CHEBI:6541
Term: losartan
Definition: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Chemical ID: MESH:D019808
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a12affects response to substanceISOSLC22A12 (Homo sapiens)6480464CTDSLC22A12 protein affects the susceptibility to LosartanPMID:18670416
Slc22a12decreases activityISOSLC22A12 (Homo sapiens)6480464CTDLosartan results in decreased activity of SLC22A12 proteinPMID:20486468
Slc22a12decreases expressionISOSLC22A12 (Homo sapiens)6480464CTDLosartan results in decreased expression of SLC22A12 mRNAPMID:20486468
Slc22a12multiple interactionsISOSLC22A12 (Homo sapiens)6480464CTD[Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric AcidPMID:18670416
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