GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ren1 | increases expression | EXP | | 6480464 | CTD | Losartan results in increased expression of REN protein | PMID:9245700 | Ren1 | multiple interactions | EXP | | 6480464 | CTD | Losartan inhibits the reaction [AGT protein results in increased expression of REN1 protein] | PMID:28578904 | Ren1 | increases activity | ISO | Ren (Rattus norvegicus) | 6480464 | CTD | Losartan results in increased activity of REN protein | PMID:9431853 | Ren1 | increases activity | ISO | REN (Homo sapiens) | 6480464 | CTD | Losartan results in increased activity of REN protein | PMID:7965263 PMID:8403307 | Ren1 | increases expression | ISO | Ren (Rattus norvegicus) | 6480464 | CTD | Losartan results in increased expression of REN mRNA; Losartan results in increased expression of REN protein | PMID:12013499 PMID:1387008 PMID:16221218 PMID:8382237 PMID:9431853 PMID:9533614 | Ren1 | multiple interactions | ISO | Ren (Rattus norvegicus) | 6480464 | CTD | [Lisinopril co-treated with Losartan] results in increased expression of REN mRNA; Losartan inhibits the reaction [Ethanol results in increased activity of REN protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein] | PMID:11709406 PMID:16221218 PMID:22982071 | Ren1 | multiple interactions | ISO | REN (Homo sapiens) | 6480464 | CTD | [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein; Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]; Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein] | PMID:12569265 PMID:28578904 PMID:9124547 | |
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