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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317785
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2c65
Name: cytochrome P450, family 2, subfamily c, polypeptide 65
Acc ID: CHEBI:6541
Term: losartan
Definition: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Chemical ID: MESH:D019808
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c65affects metabolic processingISOCYP2C9 (Homo sapiens)6480464CTDCYP2C9 protein affects the metabolism of LosartanPMID:20405111 PMID:21321060
Cyp2c65increases hydroxylationISOCYP2C9 (Homo sapiens)6480464CTDCYP2C9 protein results in increased hydroxylation of LosartanPMID:25994031
Cyp2c65increases metabolic processingISOCYP2C9 (Homo sapiens)6480464CTDCYP2C9 protein results in increased metabolism of LosartanPMID:19082874 PMID:19715737 PMID:20716633
Cyp2c65multiple interactionsISOCYP2C9 (Homo sapiens)6480464CTDCYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Losartan]; Resveratrol inhibits the reaction [CYP2C9 protein results in increased metabolism of Losartan]PMID:20716633 PMID:25994031
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