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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731911
Species: Mus musculus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:65408
Term: andrographolide
Definition: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Chemical ID: MESH:C030419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9multiple interactionsEXP 6480464CTDandrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP9 mRNA]PMID:31706003
Mmp9decreases expressionISOMMP9 (Homo sapiens)6480464CTDandrographolide results in decreased expression of MMP9 proteinPMID:35917943
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