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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:65408
Term: andrographolide
Definition: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Chemical ID: MESH:C030419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:685566480464CTDandrographolide results in decreased expression of CCND1 protein

PMID:18619950, PMID:23845849
multiple interactionsISORGD:685566480464CTDandrographolide inhibits the reaction [CCND1 protein binds to CDK4 protein]

PMID:18619950
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.