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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a2
Name: collagen type I alpha 2 chain
Acc ID: CHEBI:65408
Term: andrographolide
Definition: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Chemical ID: MESH:C030419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDandrographolide results in decreased expression of COL1A2 mRNA

PMID:29355602
decreases expressionISORGD:7309846480464CTDandrographolide results in decreased expression of COL1A2 mRNA

PMID:29355602
multiple interactionsISORGD:7309856480464CTDandrographolide inhibits the reaction [Acetaminophen results in increased expression of COL1A2 mRNA]

PMID:29355602
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.