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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2294
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccne1
Name: cyclin E1
Acc ID: CHEBI:65408
Term: andrographolide
Definition: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Chemical ID: MESH:C030419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccne1decreases expressionISOCCNE1 (Homo sapiens)6480464CTDandrographolide results in decreased expression of CCNE1 proteinPMID:23845849
Ccne1multiple interactionsISOCcne1 (Mus musculus)6480464CTDandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNE1 protein]PMID:27475717
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