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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:65408
Term: andrographolide
Definition: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Chemical ID: MESH:C030419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects foldingISOBAX (Homo sapiens)6480464CTDandrographolide affects the folding of BAX proteinPMID:19097688
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDandrographolide results in increased expression of BAX mRNA; andrographolide results in increased expression of BAX proteinPMID:23845849 PMID:24563380 PMID:35917943
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[andrographolide co-treated with Cisplatin] results in increased expression of BAX mRNA; andrographolide promotes the reaction [Cisplatin results in increased expression of BAX protein]; Fluorouracil promotes the reaction [andrographolide affects the folding of BAX protein]PMID:19097688 PMID:24563380
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