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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10836
Species: Mus musculus
RGD Object: Gene
Symbol: Kdr
Name: kinase insert domain protein receptor
Acc ID: CHEBI:65408
Term: andrographolide
Definition: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Chemical ID: MESH:C030419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kdrdecreases expressionISOKDR (Homo sapiens)6480464CTDandrographolide results in decreased expression of KDR mRNAPMID:28651835
Kdrmultiple interactionsISOKDR (Homo sapiens)6480464CTD[andrographolide co-treated with KDR protein] inhibits the reaction [VEGFA protein binds to KDR protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]PMID:24814888
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