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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10919
Species: Mus musculus
RGD Object: Gene
Symbol: Abcc1
Name: ATP-binding cassette, sub-family C member 1
Acc ID: CHEBI:6538
Term: loratadine
Definition: A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.
Chemical ID: MESH:D017336
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc1decreases response to substanceISOABCC1 (Homo sapiens)6480464CTDABCC1 protein results in decreased susceptibility to LoratadinePMID:22095822
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