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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734119
Species: Mus musculus
RGD Object: Gene
Symbol: Mmp14
Name: matrix metallopeptidase 14 (membrane-inserted)
Acc ID: CHEBI:65329
Term: LY294002
Definition: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2.
Chemical ID: MESH:C085911
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp14decreases activityEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of MMP14 proteinPMID:22326785
Mmp14decreases expressionEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP14 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP14 proteinPMID:19393235 PMID:22326785
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