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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:64983
Term: alternariol
Definition: A benzochromenone that is 6H-benzo[c]chromen-6-one which is substituted by a methyl group at position 1 and by hydroxy groups at positions 3, 7, and 9. It is the most important mycotoxin produced by the black mould Alternaria species, which are the most common mycoflora infecting small grain cereals worldwide.
Chemical ID: MESH:C005197
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1affects activityISOCYP1A1 (Homo sapiens)6480464CTDalternariol affects the activity of CYP1A1 proteinPMID:26474839
Cyp1a1affects expressionISOCYP1A1 (Homo sapiens)6480464CTDalternariol affects the expression of CYP1A1 mRNAPMID:26474839
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDalternariol results in increased expression of CYP1A1 proteinPMID:22120949
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDalternariol results in increased expression of CYP1A1 mRNAPMID:23665424
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDAHR protein affects the reaction [alternariol results in increased expression of CYP1A1 protein]; ARNT protein affects the reaction [alternariol results in increased expression of CYP1A1 protein]PMID:22120949
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