Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:6498
Term: lipoxin A4
Definition: A C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds.
Chemical ID: MESH:C040527
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bdecreases expressionISORGD:7309816480464CTDlipoxin A4 analog results in decreased expression of IL1B protein

PMID:21659618
Il1bdecreases secretionISORGD:7309816480464CTDlipoxin A4 analog results in decreased secretion of IL1B protein

PMID:10377187
Il1bmultiple interactionsISORGD:107906480464CTD2-1-carboxy-2-3-3 5-dichlorobenzyl-3H-imidazol-4-ylethylamino-4-methylpentanoic acid inhibits the reaction [lipoxin A4 inhibits the reaction [lipopolysaccharide E coli O55-B5 results in increased expression of IL1B protein]] 7-Ala-angiotensin 1-7 inhibits the reaction [lipoxin A4 inhibits the reaction [lipopolysaccharide E coli O55-B5 results in increased expression of IL1B protein]] butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [lipopolysaccharide E coli O55-B5 results in increased expression of IL1B protein]] butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]] butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanine inhibits the reaction [lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]] lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of IL1B protein] lipoxin A4 inhibits the reaction [lipopolysaccharide E coli O55-B5 results in increased expression of IL1B protein] lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] lipoxin A4 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]

PMID:10377187 PMID:21831303 PMID:29969931
Il1bmultiple interactionsISORGD:7309816480464CTDlipoxin A4 analog inhibits the reaction [TNF protein results in increased expression of IL1B mRNA] lipoxin A4 analog inhibits the reaction [TNF protein results in increased secretion of IL1B protein] lipoxin A4 inhibits the reaction [TNF protein results in increased secretion of IL1B protein]

PMID:10377187
Go Back to source page   Continue to Ontology report