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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1557793
Species: Mus musculus
RGD Object: Gene
Symbol: Fpr2
Name: formyl peptide receptor 2
Acc ID: CHEBI:6498
Term: lipoxin A4
Definition: A C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds.
Chemical ID: MESH:C040527
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fpr2increases activityISOFPR2 (Homo sapiens)6480464CTDlipoxin A4 results in increased activity of FPR2PMID:12594298
Fpr2multiple interactionsISOFPR2 (Homo sapiens)6480464CTD[Aspirin results in increased abundance of lipoxin A4] which results in increased expression of FPR2; lipoxin A4 analog binds to and results in decreased activity of FPR2 proteinPMID:12594298 PMID:19597002
Fpr2multiple interactionsISOFpr2 (Rattus norvegicus)6480464CTDlipoxin A4 inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FPR2 mRNA]PMID:21765620
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