GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sigmar1 | decreases response to substance | ISO | Sigmar1 (Mus musculus) | 6480464 | CTD | SIGMAR1 gene mutant form results in decreased susceptibility to Linuron | PMID:30661753 | Sigmar1 | increases activity | ISO | Sigmar1 (Mus musculus) | 6480464 | CTD | Linuron results in increased activity of SIGMAR1 protein | PMID:30661753 | Sigmar1 | multiple interactions | ISO | SIGMAR1 (Homo sapiens) | 6480464 | CTD | Linuron promotes the reaction [ERN1 protein binds to SIGMAR1 protein] | PMID:30661753 | Sigmar1 | multiple interactions | ISO | Sigmar1 (Mus musculus) | 6480464 | CTD | SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of ARG1 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL1 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL17 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL20 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL4 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCR2 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CSF2 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CXCL10 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IFNB1 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IFNG mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL1B mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL21 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL23A mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL6 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of MMP12 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of NOS2 mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of AHR mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of CSPG4 mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of ENTPD1 mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of IFNAR1 mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of IL10RA mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of LIF mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of TGFB2 mRNA] | PMID:30661753 | | ||||||||||||||||||||||
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