Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10823
Species: Mus musculus
RGD Object: Gene
Symbol: Jak2
Name: Janus kinase 2
Acc ID: CHEBI:64629
Term: 2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine
Definition: An organoiodine compound that is amphetamine bearing two methoxy substituents at positions 2 and 5 as well as an iodo substituent at position 4.
Chemical ID: MESH:C015952
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jak2increases phosphorylationISOJak2 (Rattus norvegicus)6480464CTD4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of JAK2 proteinPMID:31231976
Jak2multiple interactionsISOJak2 (Rattus norvegicus)6480464CTDrhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of JAK2 protein]; Tiapride Hydrochloride inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of JAK2 protein]PMID:31231976
Go Back to source page   Continue to Ontology report