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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10512
Species: Mus musculus
RGD Object: Gene
Symbol: Egr1
Name: early growth response 1
Acc ID: CHEBI:64629
Term: 2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine
Definition: An organoiodine compound that is amphetamine bearing two methoxy substituents at positions 2 and 5 as well as an iodo substituent at position 4.
Chemical ID: MESH:C015952
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egr1increases expressionEXP 6480464CTD4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of EGR1 mRNAPMID:24889602
Egr1multiple interactionsEXP 6480464CTD[Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of EGR1 mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of EGR1 mRNA]PMID:24889602
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