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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3696
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc1a1
Name: solute carrier family 1 member 1
Acc ID: CHEBI:64356
Term: pregabalin
Definition: A gamma-amino acid that is gamma-aminobutyric acid (GABA) carrying an isobutyl substitutent at the beta-position (the S-enantiomer). Binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues.
Chemical ID: MESH:D000069583
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc1a1increases activityEXP 6480464CTDPregabalin results in increased activity of SLC1A1 proteinPMID:22511482
Slc1a1multiple interactionsEXP 6480464CTDchelerythrine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; Staurosporine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; wortmannin inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]PMID:22511482
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