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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730917
Species: Homo sapiens
RGD Object: Gene
Symbol: ADM
Name: adrenomedullin
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ADMincreases expressionISOAdm (Rattus norvegicus)6480464CTDIsoproterenol results in increased expression of ADM mRNA; Isoproterenol results in increased expression of ADM proteinPMID:12732346 PMID:17250927 PMID:17306419
ADMmultiple interactionsISOAdm (Rattus norvegicus)6480464CTD[Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNA; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM protein; ADM protein inhibits the reaction [Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]]; CALCA protein inhibits the reaction [Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]]; Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]PMID:17250927 PMID:17306419
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