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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68533
Species: Homo sapiens
RGD Object: Gene
Symbol: MTOR
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MTORincreases phosphorylationISOMtor (Rattus norvegicus)6480464CTDIsoproterenol results in increased phosphorylation of MTOR proteinPMID:17623046 PMID:25045214
MTORmultiple interactionsISOMtor (Rattus norvegicus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]]PMID:17623046 PMID:25045214
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