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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62247
Species: Mus musculus
RGD Object: Gene
Symbol: Gal
Name: galanin and GMAP prepropeptide
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Galdecreases activityISOGal (Rattus norvegicus)6480464CTDIsoproterenol results in decreased activity of GAL proteinPMID:14499179 PMID:19294532
Galincreases activityISOGal (Rattus norvegicus)6480464CTDIsoproterenol results in increased activity of GAL proteinPMID:11829124 PMID:14499179 PMID:17045618 PMID:17188415 PMID:19294532 PMID:2015110
Galincreases expressionISOGal (Rattus norvegicus)6480464CTDIsoproterenol results in increased expression of GAL mRNAPMID:17182065
Galmultiple interactionsISOGal (Rattus norvegicus)6480464CTD[ferulic acid co-treated with Ascorbic Acid] inhibits the reaction [Isoproterenol results in increased activity of GAL protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GAL protein]; Betaine inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; Betaine inhibits the reaction [Isoproterenol results in increased activity of GAL protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of GAL protein]; S-allylcysteine inhibits the reaction [Isoproterenol results in increased expression of GAL mRNA]PMID:11829124 PMID:14499179 PMID:17045618 PMID:17182065 PMID:17188415 PMID:19294532
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