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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619551
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS1
Name: nitric oxide synthase 1
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS1decreases expressionISONos1 (Rattus norvegicus)6480464CTDIsoproterenol results in decreased expression of NOS1 proteinPMID:35940283
NOS1increases expressionISONos1 (Rattus norvegicus)6480464CTDIsoproterenol results in increased expression of NOS1 proteinPMID:16702995
NOS1multiple interactionsISONos1 (Rattus norvegicus)6480464CTDthymoquinone inhibits the reaction [Isoproterenol results in decreased expression of NOS1 protein]PMID:35940283
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