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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550302
Species: Mus musculus
RGD Object: Gene
Symbol: Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Acc ID: CHEBI:64310
Term: crizotinib
Definition: A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that has R configuration at the chiral centre. The active enantiomer, it acts as a kinase inhibitor and is used for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
Chemical ID: MESH:C551994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cacna1cdecreases activityISOCACNA1C (Homo sapiens)6480464CTDcrizotinib results in decreased activity of CACNA1C proteinPMID:23707608
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