GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp3 | increases cleavage | EXP | | 6480464 | CTD | 7-ketocholesterol results in increased cleavage of CASP3 protein | PMID:29065513 | Casp3 | multiple interactions | EXP | | 6480464 | CTD | alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in increased cleavage of CASP3 protein]; argan oil inhibits the reaction [7-ketocholesterol results in increased cleavage of CASP3 protein] | PMID:29065513 | Casp3 | increases activity | ISO | Casp3 (Rattus norvegicus) | 6480464 | CTD | 7-ketocholesterol results in increased activity of CASP3 protein | PMID:25845326 | Casp3 | increases activity | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | 7-ketocholesterol results in increased activity of CASP3 protein | PMID:12450566 PMID:16934673 PMID:24650663 PMID:25845326 | Casp3 | multiple interactions | ISO | Casp3 (Rattus norvegicus) | 6480464 | CTD | 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; BAY 11-7085 inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein] | PMID:25845326 | Casp3 | multiple interactions | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; BAY 11-7085 inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; beta-Tocopherol affects the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; Serotonin inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein] | PMID:12450566 PMID:24650663 PMID:25845326 | | ||||||||||||||||||||||
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