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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621120
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk4
Name: cyclin-dependent kinase 4
Acc ID: CHEBI:64227
Term: ciglitazone
Definition: An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.
Chemical ID: MESH:C039671
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk4decreases expressionEXP 6480464CTDciglitazone results in decreased expression of CDK4 mRNAPMID:20578043
Cdk4decreases expressionISOCDK4 (Homo sapiens)6480464CTDciglitazone results in decreased expression of CDK4 proteinPMID:21080969
Cdk4multiple interactionsISOCDK4 (Homo sapiens)6480464CTDCREBBP protein inhibits the reaction [ciglitazone results in decreased expression of CDK4 protein]; NCOA1 protein inhibits the reaction [ciglitazone results in decreased expression of CDK4 protein]PMID:21080969
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