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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1623009
Species: Mus musculus
RGD Object: Gene
Symbol: Tbc1d4
Name: TBC1 domain family, member 4
Acc ID: CHEBI:64227
Term: ciglitazone
Definition: An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.
Chemical ID: MESH:C039671
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tbc1d4increases phosphorylationISOTbc1d4 (Rattus norvegicus)6480464CTDciglitazone results in increased phosphorylation of TBC1D4 proteinPMID:18063688
Tbc1d4multiple interactionsISOTBC1D4 (Homo sapiens)6480464CTD[ciglitazone binds to PPARG protein] which results in increased expression of TBC1D4 mRNAPMID:16197558
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