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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10226
Species: Mus musculus
RGD Object: Gene
Symbol: Bax
Name: BCL2-associated X protein
Acc ID: CHEBI:64227
Term: ciglitazone
Definition: An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.
Chemical ID: MESH:C039671
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxaffects response to substanceISOBax (Rattus norvegicus)6480464CTDBAX mRNA affects the susceptibility to ciglitazonePMID:12065618
Baxincreases expressionISOBax (Rattus norvegicus)6480464CTDciglitazone results in increased expression of BAX proteinPMID:12065618
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDciglitazone results in increased expression of BAX proteinPMID:15492468
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Niflumic Acid co-treated with ciglitazone] results in increased activity of BAX protein; DDIT3 mutant form inhibits the reaction [[Niflumic Acid co-treated with ciglitazone] results in increased activity of BAX protein]PMID:21067863
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