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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732164
Species: Mus musculus
RGD Object: Gene
Symbol: Htr7
Name: 5-hydroxytryptamine (serotonin) receptor 7
Acc ID: CHEBI:64216
Term: metergoline
Definition: An ergoline alkaloid that is the N-benzyloxycarbonyl derivative of lysergamine. A 5-HT2 antagonist. Also 5-HT1 antagonist and 5-HT1D ligand. Has moderate affinity for 5-HT6 and high affinity for 5-HT7.
Chemical ID: MESH:D008711
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr7multiple interactionsISOHTR7 (Homo sapiens)6480464CTD[Metergoline binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; [Metergoline binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Metergoline binds to and results in decreased activity of HTR7 proteinPMID:14578406 PMID:18996971 PMID:19509219
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