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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70487
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin beta 1
Acc ID: CHEBI:64212
Term: sulindac sulfone
Definition: A sulfone metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. It inhibits the development and induces regression of premalignant adenomatous polyps. Lipoxygenase and Cox-2 inhibitor.
Chemical ID: MESH:C025463
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctnnb1decreases expressionISOCTNNB1 (Homo sapiens)6480464CTDsulindac sulfone results in decreased expression of CTNNB1 proteinPMID:10910034 PMID:12392815 PMID:14555707
Ctnnb1increases expressionISOCTNNB1 (Homo sapiens)6480464CTDsulindac sulfone results in increased expression of CTNNB1 proteinPMID:11602670
Ctnnb1multiple interactionsISOCTNNB1 (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of CTNNB1 protein]PMID:14555707
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