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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10440
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp21a1
Name: cytochrome P450, family 21, subfamily a, polypeptide 1
Acc ID: CHEBI:64211
Term: 8-Br-cAMP
Definition: A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP bearing an additional bromo substituent at position 8 on the adenine ring. An activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.
Chemical ID: MESH:D015124
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp21a1multiple interactionsEXP 6480464CTD[NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP21A1 mRNAPMID:21610156
Cyp21a1increases expressionISOCYP21A2 (Homo sapiens)6480464CTD8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP21A2 mRNAPMID:22079614 PMID:22546480 PMID:34896276
Cyp21a1multiple interactionsISOCYP21A2 (Homo sapiens)6480464CTDbifenthrin inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP21A2 mRNA]; Mitotane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP21A2 mRNA]PMID:22546480 PMID:34896276
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