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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2268
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Capn2
Name: calpain 2
Acc ID: CHEBI:64210
Term: 4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid
Definition: An amidobenzoic acid obtained by formal condensation of the carboxy group of (5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzoic acid with the anilino group of 4-aminobenzoic acid. A selective RARalpha agonist.
Chemical ID: MESH:C068073
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Capn2decreases activityISOCapn2 (Mus musculus)6480464CTDAm 580 results in decreased activity of CAPN2 proteinPMID:17460283
Capn2decreases expressionISOCapn2 (Mus musculus)6480464CTDAm 580 results in decreased expression of CAPN2 mRNAPMID:17460283
Capn2multiple interactionsISOCapn2 (Mus musculus)6480464CTDAm 580 inhibits the reaction [Hydrogen Peroxide results in increased activity of CAPN2 protein]; Am 580 inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 mRNA]PMID:17460283
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