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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10486
Species: Mus musculus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:64191
Term: nafadotride
Definition: A naphthalenecarboxamide resulting from the formal condensation of the carboxylic acid group of 4-cyano-1-methoxynaphthalene-2-carboxylic acid with the primary amino group of 1-(1-butylpyrrolidin-2-yl]methanamine. It is a highly potent, competitive, preferential dopamine D3 receptor antagonist, centrally active upon systemic administration.
Chemical ID: MESH:C097285
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd2multiple interactionsISODRD2 (Homo sapiens)6480464CTDnafadotride binds to and results in decreased activity of DRD2 proteinPMID:10728880
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