GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | decreases expression | EXP | | 6480464 | CTD | Diquat results in decreased expression of NFE2L2 mRNA; Diquat results in decreased expression of NFE2L2 protein | PMID:33475796 PMID:35268077 PMID:36572071 | Nfe2l2 | decreases response to substance | EXP | | 6480464 | CTD | NFE2L2 results in decreased susceptibility to Diquat | PMID:23056183 | Nfe2l2 | increases activity | EXP | | 6480464 | CTD | Diquat results in increased activity of NFE2L2 protein | PMID:16962985 | Nfe2l2 | increases expression | EXP | | 6480464 | CTD | Diquat results in increased expression of NFE2L2 protein | PMID:20826540 | Nfe2l2 | increases response to substance | EXP | | 6480464 | CTD | NFE2L2 gene mutant form results in increased susceptibility to Diquat | PMID:16962985 PMID:22762311 | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | [Ellagic Acid co-treated with Diquat] results in increased expression of NFE2L2 mRNA; Ascorbic Acid inhibits the reaction [Diquat results in decreased expression of NFE2L2 protein]; Ellagic Acid inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA]; KEAP1 gene mutant form inhibits the reaction [NFE2L2 gene mutant form results in increased susceptibility to Diquat]; NFE2L2 gene mutant form promotes the reaction [Diquat results in decreased abundance of Glutathione]; PROP1 protein affects the reaction [Diquat results in increased expression of NFE2L2 protein] | PMID:20826540 PMID:22762311 PMID:33475796 PMID:35268077 | Nfe2l2 | increases activity | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Diquat results in increased activity of NFE2L2 protein | PMID:20143881 PMID:21172416 | |
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